Identification of sporulation genes in Bacillus anthracis highlights similarities and significant differences with Bacillus subtilis
Fernando H. Ramírez-Guadiana, Anna P. Brogan, Yuanchen Yu, Caroline Midonet, Joel W. Sher, Ernst W. Schmid, Ian J. Roney, David Z. Rudner, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez · 2025
Read Identification of sporulation genes in Bacillus anthracis highlights similarities and significant differences with Bacillus subtilis by Fernando H. Ramírez-Guadiana, Anna P. Brogan, Yuanchen Yu, Caroline Midonet, Joel W. Sher, Ernst W. Schmid, Ian J. Roney, David Z. Rudner, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12700454.txt.
Description
Fernando Ramírez-Guadiana and co-authors map the genes that the anthrax bacterium needs to form spores, in a 2025 study. Spores are tough resting forms that let the germ persist. Most prior knowledge came from a harmless relative that has served as the lab model for over fifty years.
A genome-wide screen found more than 150 genes the pathogen needs for spore formation. Many matched the model's set, but over fifty mattered only in the pathogen, and twenty-two had no counterpart in the model at all. The team built a mutant library and studied one new gene in depth, showing how its product guards the cell wall during a key engulfing step. The tools built here will speed work on this pathogen.
Catalog record
| CREATOR | Fernando H. Ramírez-Guadiana, Anna P. Brogan, Yuanchen Yu, Caroline Midonet, Joel W. Sher, Ernst W. Schmid, Ian J. Roney, David Z. Rudner, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 126 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |