Blood RNA biomarkers and a point-of-care elastase assay for detecting host immune activation in suspected sepsis: Trajectory matters
John E. Lafleur, Eduard Shaykhinurov, John Perkins, Richard Wargowsky, Kevin Jaatinen, Mary Pasquale, Grace Holloway, David Yamane, Akhil Patel, Daniel King, Andrew Meltzer, Ryan Heidish, Soroush Shahamatdar, Aditya Loganathan, Tarun Loganathan, Taylor Bolden, Michael Zane Hayden, Aditya Maddali, Je · 2025
Read Blood RNA biomarkers and a point-of-care elastase assay for detecting host immune activation in suspected sepsis: Trajectory matters by John E. Lafleur, Eduard Shaykhinurov, John Perkins, Richard Wargowsky, Kevin Jaatinen, Mary Pasquale, Grace Holloway, David Yamane, Akhil Patel, Daniel King, Andrew Meltzer, Ryan Heidish, Soroush Shahamatdar, Aditya Loganathan, Tarun Loganathan, Taylor Bolden, Michael Zane Hayden, Aditya Maddali, Je (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12700442.txt.
Description
John Lafleur and a large team of co-authors report a 2025 study on blood tests for sepsis in the emergency department. Sepsis is a severe response to infection, and early treatment improves survival. The SENSOR study enrolled patients whose records triggered an automated sepsis alert. The team tested blood RNA markers tied to neutrophil activation.
Samples were taken during the emergency visit and compared with control samples. The team measured RNA linked to bacterial and viral infection, plus bacterial DNA in blood. They also measured an enzyme from neutrophils with a point of care test. The focus is on how marker levels change over time. Rising or falling patterns, not single values, may flag patients who will get worse.
Catalog record
| CREATOR | John E. Lafleur, Eduard Shaykhinurov, John Perkins, Richard Wargowsky, Kevin Jaatinen, Mary Pasquale, Grace Holloway, David Yamane, Akhil Patel, Daniel King, Andrew Meltzer, Ryan Heidish, Soroush Shahamatdar, Aditya Loganathan, Tarun Loganathan, Taylor Bolden, Michael Zane Hayden, Aditya Maddali, Je |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |