Synthesis, photochemical and biological evaluation of novel photoswitchable glycomimetic ligands of Pseudomonas aeruginosa LecB
Shapla Bhattacharya, Giorgia Tempra, Alessio Colleoni, Carlo Matera, Rossella Castagna, Emilio Parisini · 2025
Read Synthesis, photochemical and biological evaluation of novel photoswitchable glycomimetic ligands of Pseudomonas aeruginosa LecB by Shapla Bhattacharya, Giorgia Tempra, Alessio Colleoni, Carlo Matera, Rossella Castagna, Emilio Parisini (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12700220.txt.
Description
Shapla Bhattacharya and co-authors build light-switchable sugar-like compounds against a resistant bacterium in this 2025 paper. Drug-resistant bacteria are a growing global threat, fed by heavy antibiotic use and hospital spread. Pseudomonas aeruginosa is a key offender in lung infections.
Their compounds mimic sugars and bind a bacterial protein called LecB. Light flips the compounds between forms, turning activity on or off with fine control. This field, called photopharmacology, aims for precise timing and placement of drug action. The team made the compounds and tested their light and biological behavior. Switchable anti-bacterial tools could one day cut resistance by dosing only where needed. The hope is to hit the germ hard and spare the rest of the body, so dose can stay low and side effects stay small.
Catalog record
| CREATOR | Shapla Bhattacharya, Giorgia Tempra, Alessio Colleoni, Carlo Matera, Rossella Castagna, Emilio Parisini |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |