A fluorescent probe for concurrent detection of cysteine, homocysteine, and superoxide anion
Yang Li, Ting Yu, Zhaoxin Wang, Jialing Wang, Yuquan Tang, Youyu Zhang, Haitao Li, Huijun Zhou, Peng Yin, Shouzhuo Yao · 2025
Read A fluorescent probe for concurrent detection of cysteine, homocysteine, and superoxide anion by Yang Li, Ting Yu, Zhaoxin Wang, Jialing Wang, Yuquan Tang, Youyu Zhang, Haitao Li, Huijun Zhou, Peng Yin, Shouzhuo Yao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12700212.txt.
Description
Yang Li and nine co-authors report a fluorescent probe that detects three redox molecules at once in living systems. Cysteine, homocysteine, and superoxide anion all help hold redox balance, and their disruption drives oxidative stress in diseases such as epilepsy and liver injury. Tracking all three together has been hard with single target probes.
The probe, called BPC, is sensitive, selective, and gentle on cells. It visualizes redox shifts in real time in living cells and zebrafish. In drug induced models of epilepsy and liver injury, the probe reveals clear changes in all three target levels. It also tracks recovery after treatment with a standard antioxidant drug. The tool opens a window on redox biology for diagnosis research.
Catalog record
| CREATOR | Yang Li, Ting Yu, Zhaoxin Wang, Jialing Wang, Yuquan Tang, Youyu Zhang, Haitao Li, Huijun Zhou, Peng Yin, Shouzhuo Yao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |