Total synthesis of zwitterionic PS A2 oligosaccharides from Bacteroides fragilis
Xinxin Li, Qingzhi Pan-Gao, Yongyong Wan, Fuxing Zeng, Jianying Qi, Yuanhong Tu, Liming Wang, Zhen Wang, Jeroen D. C. Codée, Qingju Zhang · 2025
Read Total synthesis of zwitterionic PS A2 oligosaccharides from Bacteroides fragilis by Xinxin Li, Qingzhi Pan-Gao, Yongyong Wan, Fuxing Zeng, Jianying Qi, Yuanhong Tu, Liming Wang, Zhen Wang, Jeroen D. C. Codée, Qingju Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12700203.txt.
Description
Xinxin Li and nine co-authors build rare bacterial sugars atom by atom in the lab. Their 2025 paper reports the total synthesis of PS A2 pieces from Bacteroides fragilis. These sugars carry both positive and negative charges, a rare zwitterionic trait. That trait lets them stir T cell responses, unlike most sugars.
Two lengths were made: a five-sugar piece and a ten-sugar double unit. A convergent plan joined blocks with careful control of bond shapes. A tricky side chain on one sugar needed a custom route. Such hand-made copies can reveal how the sugars talk to the immune system. They may also replace carrier proteins in future carbohydrate vaccines. Pure material is the first step to both goals.
Catalog record
| CREATOR | Xinxin Li, Qingzhi Pan-Gao, Yongyong Wan, Fuxing Zeng, Jianying Qi, Yuanhong Tu, Liming Wang, Zhen Wang, Jeroen D. C. Codée, Qingju Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |