Integrated single-cell atlases unveil the operation principles of whole-brain 5-HT neuronal subsystems
Ziqi Song, Chun-Xiao Huang, Huixian Zhang, Chuanzhe Ye, Na Guan, Jianren Song · 2025
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Description
Ziqi Song and co-authors build single cell atlases of the serotonin neuron system in zebrafish, in a 2025 paper. How these brain subsystems run matters for many body and behavior outcomes, but data limits slowed study. Their resources pair a projection dataset, two gene survey datasets, and a whole brain imaging database.
The joined analysis found seven distinct subgroups. Each had its own axon pattern, cell body site, and gene profile. Neurons were uniform inside a subgroup but differed across subgroups. Each subsystem acts as a module serving several tasks, not one, and most tasks need several subsystems acting in parallel. The pattern may also guide study of these neurons in mammals.
Catalog record
| CREATOR | Ziqi Song, Chun-Xiao Huang, Huixian Zhang, Chuanzhe Ye, Na Guan, Jianren Song |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |