Dual roles of complement in ulcerative colitis: insights from clinical studies and animal research
Zeyi Qin, Ruoxiang Wang, Yi Zhang · 2025
Read Dual roles of complement in ulcerative colitis: insights from clinical studies and animal research by Zeyi Qin, Ruoxiang Wang, Yi Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12699900.txt.
Description
Zeyi Qin, Ruoxiang Wang, and Yi Zhang review in 2025 the two faced role of the complement system in ulcerative colitis. The disease is a chronic inflammation of the colon lining that breaks its barrier. Complement, a blood protein cascade of the immune system, steers much of that process.
Studies in patients and in mouse colitis models show the system cutting both ways. Some of its parts pour fuel on the fire, drawing in white cells and unleashing signal storms that injure the lining. Other parts protect: they clear dead cells, calm immune responses, and aid repair. A therapy that blocks the whole system could thus do harm as well as good. The review argues for precise drugs that spare the protective arm.
Catalog record
| CREATOR | Zeyi Qin, Ruoxiang Wang, Yi Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |