Lipofuscin accumulation in aging and neurodegeneration: a potential “timebomb” overlooked in Alzheimer’s disease
Godfried Dougnon, Hideaki Matsui · 2025
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Description
Godfried Dougnon and Hideaki Matsui wrote this 2025 review of a waste pigment that builds up in aging brains. The pigment, called lipofuscin, gathers as glowing granules inside neurons and immune cells of the brain. It was long dismissed as inert trash left by cell breakdown.
The authors argue it may act as a slow time bomb in diseases like Alzheimer's. They pose sharp questions: why does it gather in old brain cells, what happens when those cells die, and why do plaques start in grey matter late in life? The review gathers proof that the pigment may sway how nerve disease unfolds, not just mark it.
Catalog record
| CREATOR | Godfried Dougnon, Hideaki Matsui |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |