Aberrant lipid metabolism reshapes the immune landscape in bone metastasis of nasopharyngeal carcinoma
Yuanyuan Feng, Hongmei Wang, Ziyan Zhu, Wenxiang Deng, Xiaoyue He, Yingying Yao, Miao Song, Xiaohong Peng, Yanling Lin, Longmei Cai · 2025
Read Aberrant lipid metabolism reshapes the immune landscape in bone metastasis of nasopharyngeal carcinoma by Yuanyuan Feng, Hongmei Wang, Ziyan Zhu, Wenxiang Deng, Xiaoyue He, Yingying Yao, Miao Song, Xiaohong Peng, Yanling Lin, Longmei Cai (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12699725.txt.
Description
Yuanyuan Feng leads a team of ten authors in 2025 in tracing how fat chemistry gone wrong helps a throat cancer spread to bone while hiding from the immune system. Nasopharyngeal carcinoma that reaches bone resists treatment and kills, and tumor metabolites were suspected of coaching that spread.
Their multi-layer analysis found the bone tumors oddly empty of immune cells. One enzyme, sphingosine kinase 1, stood out as a driver: it produces a fat signal that both pushes metastasis and keeps immune cells out. Naming that mediator gives drug developers a target where metabolism and immunity meet.
Catalog record
| CREATOR | Yuanyuan Feng, Hongmei Wang, Ziyan Zhu, Wenxiang Deng, Xiaoyue He, Yingying Yao, Miao Song, Xiaohong Peng, Yanling Lin, Longmei Cai |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |