Exploring a panel of serum biomarkers for cancer risk in patients with non-specific symptoms: a comparative analysis of feature selection methods
Maria Jose Monroy-Iglesias, Aida Santaolalla, Sabine Martin, Bernard North, Charlotte Moss, Kate Haire, Geraint Jones, Lindsay Steward, Carlos Cargaleiro, Flaminia Bruno, Juliet Millwaters, Chandra Basyal, Sarah Weild, Beth Russell, Mieke Van Hemelrijck, Saoirse Dolly · 2025
Read Exploring a panel of serum biomarkers for cancer risk in patients with non-specific symptoms: a comparative analysis of feature selection methods by Maria Jose Monroy-Iglesias, Aida Santaolalla, Sabine Martin, Bernard North, Charlotte Moss, Kate Haire, Geraint Jones, Lindsay Steward, Carlos Cargaleiro, Flaminia Bruno, Juliet Millwaters, Chandra Basyal, Sarah Weild, Beth Russell, Mieke Van Hemelrijck, Saoirse Dolly (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12699618.txt.
Description
Maria Monroy-Iglesias and co-authors test blood marker panels to sort cancer risk in patients with vague symptoms. Their 2025 study comes from rapid diagnostic clinics in London, where most such patients prove cancer-free. Better sorting would aim deep tests at those who need them most.
Near six thousand clinic patients fed two score-building methods. One used latent class analysis and one used a shrinkage method. Each picked a set of markers, from white cell counts to inflammation signs. Both scores sorted risk well, and a score of two or more marked much higher cancer odds. A second clinic's data confirmed the forecast. The authors offer the scores for targeted diagnostic planning.
Catalog record
| CREATOR | Maria Jose Monroy-Iglesias, Aida Santaolalla, Sabine Martin, Bernard North, Charlotte Moss, Kate Haire, Geraint Jones, Lindsay Steward, Carlos Cargaleiro, Flaminia Bruno, Juliet Millwaters, Chandra Basyal, Sarah Weild, Beth Russell, Mieke Van Hemelrijck, Saoirse Dolly |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |