ALKBH5 gene polymorphisms and Wilms tumour susceptibility in children from East China: a case–control study
Jiabin Yu, Yizhen Wang, Shouhua Zhang, Haixia Zhou, Shaohua He, Ruixi Hua, Wanfu Li, Chunlei Zhou, Hongting Lu · 2025
Read ALKBH5 gene polymorphisms and Wilms tumour susceptibility in children from East China: a case–control study by Jiabin Yu, Yizhen Wang, Shouhua Zhang, Haixia Zhou, Shaohua He, Ruixi Hua, Wanfu Li, Chunlei Zhou, Hongting Lu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12699568.txt.
Description
Jiabin Yu and co-authors study in 2025 whether variants in a gene called ALKBH5 affect risk of Wilms tumour, the most common kidney cancer in children. The gene removes a chemical mark from RNA and has been tied to other cancers. Its role in this childhood tumour was largely unknown.
The case-control study included 416 patients and 936 healthy controls from East China. One variant form raised risk notably, and carrying two risk genotypes raised it further. The effect was stronger in girls, older children, and early-stage cases. The authors suggest the variant marks higher susceptibility in this population.
Catalog record
| CREATOR | Jiabin Yu, Yizhen Wang, Shouhua Zhang, Haixia Zhou, Shaohua He, Ruixi Hua, Wanfu Li, Chunlei Zhou, Hongting Lu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |