Investigating the causal role of circulating metabolites in major depressive disorder
Li Fu, Ancha Baranova, Hongbao Cao, Fuquan Zhang · 2025
Read Investigating the causal role of circulating metabolites in major depressive disorder by Li Fu, Ancha Baranova, Hongbao Cao, Fuquan Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12699549.txt.
Description
Li Fu and co-authors use gene lots to test if blood chemicals cause major depression, in a study from 2025. Mood and metabolism are kin, but kin ties do not prove cause. Gene lots, dealt at birth, can mimic a trial: if a chemical's gene marks track the ill, cause is apt.
The pool set 871 blood chemicals against the ill in vast gene banks, more than a million souls for the mood side. Eleven chemicals passed the bar. Eight leaned guard, one a fat part of cell skins among them; three leaned risk, each by a hair. Twin-source checks and drug worth scans flagged which of the eleven could be drug leads. The team frames the list as a map for lab proof, not proof itself.
Catalog record
| CREATOR | Li Fu, Ancha Baranova, Hongbao Cao, Fuquan Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |