Metabolic reprogramming by pseudorabies virus: nucleotide metabolism as a central vulnerability for viral replication and pathogenesis
Xiaoyong Chen, Qingsen Wang, Xi Chen · 2025
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Description
Chen, Wang, and Chen profile how a pig herpesvirus rewires cell chemistry to feed its own copying, pinpointing the building blocks of DNA as the choke point. The virus causes brain and breeding disease in swine and threatens farms worldwide. Their 2025 study reads thousands of small molecules in infected pig kidney cells and pairs the survey with gene activity checks.
Infected cells split cleanly from healthy ones in chemical profile. Membrane fat chemistry sank, while protein-building and sugar-tagging routes rose. The sharpest rise hit nucleotide metabolism, the supply line for viral genomes, with its key genes switching on over time. The authors propose starving that supply line as an antiviral strategy.
Catalog record
| CREATOR | Xiaoyong Chen, Qingsen Wang, Xi Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |