What is in a name? Rethinking SMUG1 in genome maintenance
Natalie Rudolfova, Alexander Myhr Skjetne, Nicola P Montaldo, Torkild Visnes, Hilde Loge Nilsen, Maurice Michel · 2025
Read What is in a name? Rethinking SMUG1 in genome maintenance by Natalie Rudolfova, Alexander Myhr Skjetne, Nicola P Montaldo, Torkild Visnes, Hilde Loge Nilsen, Maurice Michel (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12699328.txt.
Description
Natalie Rudolfova and co-authors argue that an enzyme called SMUG1 does far more than its name suggests. Their 2025 review covers this DNA repair enzyme, whose full name ties it to cutting uracil out of single strands of DNA. In fact it handles many kinds of small DNA damage, prefers double strands, and can also cut the backbone itself.
Beyond repair, the enzyme helps control RNA quality and production. New work links it with proteins that guard copying forks when DNA replication is stressed, giving it a role in cancer cell survival. The authors say mapping its full range is the key to judging it as a possible drug target.
Catalog record
| CREATOR | Natalie Rudolfova, Alexander Myhr Skjetne, Nicola P Montaldo, Torkild Visnes, Hilde Loge Nilsen, Maurice Michel |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |