Integrated Colorisensing Platform with Microneedles and Metal-Phenol Nanozymes for Point-of-Care Testings of Acetylcholinesterase Activity and Its Drug Inhibitor
Erlin Chen, Peng Chang, Haibin Xu, Hongxing Xu, Zhiqiang Zhu, Danfeng Shen · 2025
Read Integrated Colorisensing Platform with Microneedles and Metal-Phenol Nanozymes for Point-of-Care Testings of Acetylcholinesterase Activity and Its Drug Inhibitor by Erlin Chen, Peng Chang, Haibin Xu, Hongxing Xu, Zhiqiang Zhu, Danfeng Shen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12698867.txt.
Description
Erlin Chen and co-authors build in this 2025 study a pocket test for an enzyme whose activity flags nerve disease. Acetylcholinesterase levels matter in disorders like Alzheimer's, and its blockers are candidate drugs. Their platform pairs a microneedle patch with iron-based nanozyme rods that mimic an enzyme and drive a color change.
The target enzyme's product switches the nanozyme off, so color fades in proportion to activity, read by a phone camera. The sensor proved keen and selective, with a very low detection limit and a range spanning five orders of size. It matched the standard lab method and served to screen a plant compound as a blocker. Clinics could run the test at the bedside.
Catalog record
| CREATOR | Erlin Chen, Peng Chang, Haibin Xu, Hongxing Xu, Zhiqiang Zhu, Danfeng Shen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |