Conductive Nerve Guidance Conduits Loaded With Adipose Mesenchymal Stem Cells for Peripheral Nerve Regeneration
Hong Cheng, Yangnan Hu, Menghui Liao, Xinyi Pang, Hui Zhang, Meihan Yu, Bin Zhang, Yu Wang, Huan Wang, Tingting Liu, Renjie Chai · 2025
Read Conductive Nerve Guidance Conduits Loaded With Adipose Mesenchymal Stem Cells for Peripheral Nerve Regeneration by Hong Cheng, Yangnan Hu, Menghui Liao, Xinyi Pang, Hui Zhang, Meihan Yu, Bin Zhang, Yu Wang, Huan Wang, Tingting Liu, Renjie Chai (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12697924.txt.
Description
Hong Cheng and co-authors built a living, electrically conductive tube to bridge cut peripheral nerves in rats. Nerve grafts from the patient are the standard repair, but they cost a second injury site. Artificial guide tubes often lack the biological and electrical cues nerves want. The team's tube combines carbon nanotubes coated in silk protein, for conductivity, with fat-derived stem cells that steadily release growth factors. Together they form a supportive, signal-rich path for regrowing fibers.
In rats with a ten-millimeter sciatic gap, the loaded tubes matched real grafts: similar counts of new nerve cells, similar fiber regrowth, and nearly identical walking-function scores at twelve weeks. Histology showed the fullest regeneration in the combined group. The authors propose the design as a tissue-engineered stand-in for grafts. Matching the gold standard in animals is the bar for human talk, and this conduit cleared it.
Catalog record
| CREATOR | Hong Cheng, Yangnan Hu, Menghui Liao, Xinyi Pang, Hui Zhang, Meihan Yu, Bin Zhang, Yu Wang, Huan Wang, Tingting Liu, Renjie Chai |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |