A double-blind replication attempt of offline 5Hz-rTUS-induced corticospinal excitability
Po-Yu Fong, Benjamin R Kop, Carys Evans, Vidya Gani Wijaya, Yongling Lin, Drew Cappotto, Jenny SA Lee, Anna Latorre, Joy Song, Bradley Treeby, Eleanor Martin, John Rothwell, Lennart Verhagen, Sven Bestmann · 2025
Read A double-blind replication attempt of offline 5Hz-rTUS-induced corticospinal excitability by Po-Yu Fong, Benjamin R Kop, Carys Evans, Vidya Gani Wijaya, Yongling Lin, Drew Cappotto, Jenny SA Lee, Anna Latorre, Joy Song, Bradley Treeby, Eleanor Martin, John Rothwell, Lennart Verhagen, Sven Bestmann (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12696668.txt.
Description
Po-Yu Fong and co-authors report a careful attempt to repeat a headline ultrasound brain stimulation result in a 2025 paper. Gentle focused ultrasound has been claimed to leave the motor cortex more excitable for a while after pulsing. The original report found large effects, which made a blinded rerun worthwhile.
Volunteers got real or sham pulsing with neither side knowing which, guided by precise neuronavigation. Personal sound simulations checked that the target truly got dosed. Muscle response thresholds and sizes did not budge between real and sham arms. The null result tempers early excitement and shows the value of pre-registered reruns.
Catalog record
| CREATOR | Po-Yu Fong, Benjamin R Kop, Carys Evans, Vidya Gani Wijaya, Yongling Lin, Drew Cappotto, Jenny SA Lee, Anna Latorre, Joy Song, Bradley Treeby, Eleanor Martin, John Rothwell, Lennart Verhagen, Sven Bestmann |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |