m6A‐Mediated Stabilization of PRMT9 mRNA by IGF2BP1 Drives Proliferation and Metastasis in Lung Adenocarcinoma
Jinghua Chen, Jiahao Yang, Zihao Chen, Xiangpeng Chu · 2025
Read m6A‐Mediated Stabilization of PRMT9 mRNA by IGF2BP1 Drives Proliferation and Metastasis in Lung Adenocarcinoma by Jinghua Chen, Jiahao Yang, Zihao Chen, Xiangpeng Chu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12696393.txt.
Description
Jinghua Chen, Jiahao Yang, Zihao Chen, and Xiangpeng Chu study a gene that helps lung cancer spread, in a 2025 paper. The gene, PRMT9, is overactive in lung adenocarcinoma, the most common lung cancer type, and the team set out to learn what it does and why it runs high.
In tumor samples and cell lines, the gene and its protein both ran well above normal levels. Silencing it sharply cut the cells' power to move and invade, and dimmed a key growth pathway. The cause of the high levels turned out to be a chemical tag on the gene's message that steadies it, applied with the help of a reader protein. Blocking the growth path and tests in mice backed the chain of events.
Catalog record
| CREATOR | Jinghua Chen, Jiahao Yang, Zihao Chen, Xiangpeng Chu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |