GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
Gregory Austin, Affiong I. Oqua, Liliane El Eid, Mingli Zhu, Yusman Manchanda, Priyanka Peres, Helena Coyle, Yelyzaveta Poliakova, Zhanna Balkhiyarova, Karim Bouzakri, Alex Montoya, Dominic J. Withers, Michele Solimena, Ben Jones, Steven J. Millership, Steffen Burgold, David C. A. Gaboriau, Endre Ma · 2025
Read GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function by Gregory Austin, Affiong I. Oqua, Liliane El Eid, Mingli Zhu, Yusman Manchanda, Priyanka Peres, Helena Coyle, Yelyzaveta Poliakova, Zhanna Balkhiyarova, Karim Bouzakri, Alex Montoya, Dominic J. Withers, Michele Solimena, Ben Jones, Steven J. Millership, Steffen Burgold, David C. A. Gaboriau, Endre Ma (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12696101.txt.
Description
Gregory Austin and a large team of co-authors published a study in 2025 on how diabetes drug targets reshape the powerhouses of insulin-making cells. Drugs that mimic a gut hormone help these cells, partly by renewing their mitochondria. How the hormone's receptor talks to those powerhouses was not known, so the team traced the contact points inside the cell.
Working in cell lines and donated pancreatic tissue, they found the active receptor travels to meeting sites between two cell compartments. There it joins two partner proteins and triggers local signaling. That signaling changes the inner scaffolding of mitochondria and how they are recycled. The pathway may explain part of how these widely used drugs protect cells in type 2 diabetes.
Catalog record
| CREATOR | Gregory Austin, Affiong I. Oqua, Liliane El Eid, Mingli Zhu, Yusman Manchanda, Priyanka Peres, Helena Coyle, Yelyzaveta Poliakova, Zhanna Balkhiyarova, Karim Bouzakri, Alex Montoya, Dominic J. Withers, Michele Solimena, Ben Jones, Steven J. Millership, Steffen Burgold, David C. A. Gaboriau, Endre Ma |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 134 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |