Perioperative switching to lemborexant for prevention of delirium in older cancer patients with insomnia taking GABAA receptor agonists: a retrospective study
Tatsuto Terada, Takatoshi Hirayama, Ryoichi Sadahiro, Saho Wada, Junji Yamaguchi, Eri Nishikawa, Rika Nakahara, Shinsuke Washizuka, Hiromichi Matsuoka · 2025
Read Perioperative switching to lemborexant for prevention of delirium in older cancer patients with insomnia taking GABAA receptor agonists: a retrospective study by Tatsuto Terada, Takatoshi Hirayama, Ryoichi Sadahiro, Saho Wada, Junji Yamaguchi, Eri Nishikawa, Rika Nakahara, Shinsuke Washizuka, Hiromichi Matsuoka (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12696088.txt.
Description
Tatsuto Terada and co-authors report a 2025 study on preventing delirium after surgery in older cancer patients. Delirium strikes about a third of patients after an operation, and the risk grows with age. Many of these patients take sleep drugs that raise the risk, yet stopping them can also cause harm.
The team looked back at patients aged 75 and older at a national cancer center in Japan. All had taken a daily sleep drug of the risky class before surgery. Some were switched to a newer sleep drug, lemborexant, before their operation. Delirium appeared in 1 of 17 patients in the switch group, against 15 of 33 in the group that stayed on the old drug. The gap hints that the switch may guard the brain after surgery.
Catalog record
| CREATOR | Tatsuto Terada, Takatoshi Hirayama, Ryoichi Sadahiro, Saho Wada, Junji Yamaguchi, Eri Nishikawa, Rika Nakahara, Shinsuke Washizuka, Hiromichi Matsuoka |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |