Systematic identification of bacterial factors driving Staphylococcus aureus intracellular lifestyle in non-professional phagocytes
Ines Rodrigues Lopes, Laura Maria Alcantara, Maria Lopez-Bravo, Yi Liu, Gerald Larrouy-Maumus, Daniel Lopez, Miguel Mano, Ana Eulalio · 2025
Read Systematic identification of bacterial factors driving Staphylococcus aureus intracellular lifestyle in non-professional phagocytes by Ines Rodrigues Lopes, Laura Maria Alcantara, Maria Lopez-Bravo, Yi Liu, Gerald Larrouy-Maumus, Daniel Lopez, Miguel Mano, Ana Eulalio (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12696020.txt.
Description
Ines Rodrigues Lopes and co-authors published a research paper in 2025 mapping which bacterial genes Staphylococcus aureus needs to live inside ordinary body cells. The germ is famous for surface infections, but it can also hide inside cells, dodging immunity and antibiotics. The team screened a library of nearly two thousand mutants in epithelial cells over two days.
Seventy-three factors strongly shaped invasion, growth, persistence, or host damage, most never linked to the indoor lifestyle before. One enzyme stood out: it tunes a master virulence switch through the cell's redox state. The catalog gives drug hunters fresh targets against the sheltered bacterial population that standard treatment misses.
Catalog record
| CREATOR | Ines Rodrigues Lopes, Laura Maria Alcantara, Maria Lopez-Bravo, Yi Liu, Gerald Larrouy-Maumus, Daniel Lopez, Miguel Mano, Ana Eulalio |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |