Single-cell transcriptomic analysis reveals a systemic immune dysregulation in intravenous immunoglobulin non-responsive Kawasaki disease
Chenhui Feng, Qirui Li, Minna Yang, Yeshi Chen, Mingming Zhang, Hongmao Wang, Xiaohui Li · 2025
Read Single-cell transcriptomic analysis reveals a systemic immune dysregulation in intravenous immunoglobulin non-responsive Kawasaki disease by Chenhui Feng, Qirui Li, Minna Yang, Yeshi Chen, Mingming Zhang, Hongmao Wang, Xiaohui Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12695851.txt.
Description
BackgroundIntravenous immunoglobulin (IVIG) has been established as the first-line treatment for Kawasaki disease (KD). However, 10%–20% of patients are unresponsive, increasing their risk of coronary artery complications.MethodsTo elucidate the pathogenesis of IVIG non-responsiveness, we performed single-cell transcriptomic profiling on 24 peripheral blood mononuclear cell (PBMC) samples from responsive and non-responsive KD patients before and after IVIG treatment.
Catalog record
| CREATOR | Chenhui Feng, Qirui Li, Minna Yang, Yeshi Chen, Mingming Zhang, Hongmao Wang, Xiaohui Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |