Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stromal cells
Huijie Lai, Jinjin Jia, Zijun Kuang, Jie Lu, Yuyan Zeng · 2025
Read Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stromal cells by Huijie Lai, Jinjin Jia, Zijun Kuang, Jie Lu, Yuyan Zeng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12695794.txt.
Description
Huijie Lai and co-authors probe how a classic Chinese herbal brew acts on misplaced womb tissue, in this 2025 study. The brew, Shaoyao Gancao decoction, is long used for cramp and pain, including gynecological pain. The team studied cells from adenomyosis lesions, where womb lining grows into the muscle wall.
In the lesions, a small RNA switch was turned up and a growth pathway ran hot, while cell self-cleaning ran low. Serum from brew-treated animals reversed those shifts: the switch and pathway eased, a brake gene rose, self-cleaning increased, and cell death grew. The authors map a route for the brew's effect.
Catalog record
| CREATOR | Huijie Lai, Jinjin Jia, Zijun Kuang, Jie Lu, Yuyan Zeng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |