Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathway in budding yeast
Prakhar Agarwal, Anushka Alekar, Shubhomita Mallick, Kannan Harini, Santanu K Ghosh, Yamini Dalal · 2025
Read Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathway in budding yeast by Prakhar Agarwal, Anushka Alekar, Shubhomita Mallick, Kannan Harini, Santanu K Ghosh, Yamini Dalal (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12695027.txt.
Description
A team of yeast biologists finds a second job for a centromere protein handler in a paper from 2025. The catalog adds a sixth author absent from the head byline, so team framing is used here. The chaperone, Scm3, normally installs a special histone at centromeres. Cells drained of it proved sensitive to DNA damage. It also interacted genetically with a known repair mutant and failed to trigger damage arrest properly.
The protein gathers at damage sites and gets chemically modified after injury. Related findings in human cells point the same way. The authors conclude this chaperone family guards the genome through two pathways. That dual role could matter for diseases of chromosome mis-segregation.
Catalog record
| CREATOR | Prakhar Agarwal, Anushka Alekar, Shubhomita Mallick, Kannan Harini, Santanu K Ghosh, Yamini Dalal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 169 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |