Lipid Metabolism–Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets
Paalki Sethi, Awdhesh Kumar Mishra, Shampa Ghosh, Krishna Kumar Singh, Samarth Sharma, Radoslav Stojchevski, Dimiter Avtanski, Jitendra Kumar Sinha · 2025
Read Lipid Metabolism–Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets by Paalki Sethi, Awdhesh Kumar Mishra, Shampa Ghosh, Krishna Kumar Singh, Samarth Sharma, Radoslav Stojchevski, Dimiter Avtanski, Jitendra Kumar Sinha (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12693963.txt.
Description
Lipid metabolism and lipid-derived signaling together ensure cellular and systemic homeostasis. Their dysregulation causes obesity, type 2 diabetes, cardiovascular disease, NAFLD/MASH, and neurodegeneration throughout life. This review integrates central pathways, such as ACC–FASN-mediated de novo lipogenesis, lipid-droplet lipolysis, and mitochondrial and peroxisomal β-oxidation, and their regulation by insulin–PI3K–Akt, glucagon–cAMP–PKA, SREBPs, PPARs, and AMPK.
Catalog record
| CREATOR | Paalki Sethi, Awdhesh Kumar Mishra, Shampa Ghosh, Krishna Kumar Singh, Samarth Sharma, Radoslav Stojchevski, Dimiter Avtanski, Jitendra Kumar Sinha |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |