Directed Evolution of AtMP2 Peptide: Unlocking Enhanced Antibacterial Potential from Anabas testudineus
Li Ting Lee, Arnold Ang, Ahmed Najm, Adura Mohd Adnan, Akram Mohd Nordin, Ibrahim Mahmood, Sarantuya Dunkhorol, Shazrul Fazry, Douglas Law · 2025
Read Directed Evolution of AtMP2 Peptide: Unlocking Enhanced Antibacterial Potential from Anabas testudineus by Li Ting Lee, Arnold Ang, Ahmed Najm, Adura Mohd Adnan, Akram Mohd Nordin, Ibrahim Mahmood, Sarantuya Dunkhorol, Shazrul Fazry, Douglas Law (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12693613.txt.
Description
Li Ting Lee and co-authors published this 2025 study on germ-fighting peptides from a freshwater fish. The climbing perch makes peptides in its skin mucus that can kill bacteria. Earlier work found two such peptides, and one, AtMP2, also fought cancer cells in tests. The team asked whether tuned versions of AtMP2 could kill germs even better.
They used a guided change process to breed new variants on the computer, then scored them with three prediction tools. Two variants were made and tested in the lab. Both beat the original against the Gram-positive germ group. At a set dose, both also proved safe for the human and animal cell lines tested. The work points toward new germ-fighting drugs drawn from fish defenses.
Catalog record
| CREATOR | Li Ting Lee, Arnold Ang, Ahmed Najm, Adura Mohd Adnan, Akram Mohd Nordin, Ibrahim Mahmood, Sarantuya Dunkhorol, Shazrul Fazry, Douglas Law |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |