Multi-Pathway Mechanisms of Engeletin in Ischemic Stroke: A Comprehensive Study Based on Network Pharmacology, Machine Learning, and Immune Infiltration Analysis
Huiming Xue, Yuchen Wen, Jiahui Yang, Yue Zhang, Chang Jin, Bing Li, Yongxing Ai, Meizhu Zheng, Boge Wen, Kai Song · 2025
Read Multi-Pathway Mechanisms of Engeletin in Ischemic Stroke: A Comprehensive Study Based on Network Pharmacology, Machine Learning, and Immune Infiltration Analysis by Huiming Xue, Yuchen Wen, Jiahui Yang, Yue Zhang, Chang Jin, Bing Li, Yongxing Ai, Meizhu Zheng, Boge Wen, Kai Song (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12692429.txt.
Description
A peer-reviewed research article from Europe PMC (2025). Ischemic stroke (IS) is a leading cause of mortality and long-term disability, underpinned by complex molecular mechanisms, such as oxidative stress, neuroinflammation, and apoptosis. The flavonoid Engeletin exhibits promising neuroprotective properties, but its mechanism of action remains largely unknown. In this study, we employed a systems biology approach, combined with artificial intelligence (AI), to uncover the multitarget mechanisms of Engeletin in IS. Potential targets were predicted using SwissTargetPrediction and PharmMapper and were found to intersect with IS-related genes from multiple disease databases.
Catalog record
| CREATOR | Huiming Xue, Yuchen Wen, Jiahui Yang, Yue Zhang, Chang Jin, Bing Li, Yongxing Ai, Meizhu Zheng, Boge Wen, Kai Song |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |