Chronic Overexpression of Neuronal NRG1-III in Mice Causes Long-Term Detrimental Changes in Lower Motor Neurons, Neuromuscular Synapses and Motor Behaviour
Sara Salvany, Sara Hernández, Anna Casanovas, Sílvia Gras, Lídia Piedrafita, Mar Bosch-Queralt, Markus H Schwab, Jordi Calderó, Josep E Esquerda, Olga Tarabal, Fabrizio Michetti · 2025
Read Chronic Overexpression of Neuronal NRG1-III in Mice Causes Long-Term Detrimental Changes in Lower Motor Neurons, Neuromuscular Synapses and Motor Behaviour by Sara Salvany, Sara Hernández, Anna Casanovas, Sílvia Gras, Lídia Piedrafita, Mar Bosch-Queralt, Markus H Schwab, Jordi Calderó, Josep E Esquerda, Olga Tarabal, Fabrizio Michetti (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12692416.txt.
Description
A peer-reviewed research article from Europe PMC (2025). Neuregulins (NRGs) are ligands of tyrosine kinase receptors from the ErbB family and play multiple developmental roles. NRG1–ErbB signaling regulates myelination and has been associated with amyotrophic lateral sclerosis (ALS) pathology. Given the potential therapeutic relevance of this pathway for motor neuron (MN) diseases, we employed a transgenic (TG) mouse with persistent neuronal overexpression of neuregulin type III (NRG1-III) to investigate its impact on the neuromuscular system.
Catalog record
| CREATOR | Sara Salvany, Sara Hernández, Anna Casanovas, Sílvia Gras, Lídia Piedrafita, Mar Bosch-Queralt, Markus H Schwab, Jordi Calderó, Josep E Esquerda, Olga Tarabal, Fabrizio Michetti |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |