Comprehensive Genomic Profiling of Small-Cell Lung Cancer Reveals Frequent Potentially Targetable Alterations
Dániel Schmalz, Zoltán Krabóth, Veronika Czoma, Péter Urbán, Attila Gyenesei, István Ruzsics, Veronika Sárosi, Árpád Boronkai, Emőke Papp, Béla Kajtár, Maria Gazouli · 2025
Read Comprehensive Genomic Profiling of Small-Cell Lung Cancer Reveals Frequent Potentially Targetable Alterations by Dániel Schmalz, Zoltán Krabóth, Veronika Czoma, Péter Urbán, Attila Gyenesei, István Ruzsics, Veronika Sárosi, Árpád Boronkai, Emőke Papp, Béla Kajtár, Maria Gazouli (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12692088.txt.
Description
Daniel Schmalz and co-authors profile the genomes of small cell lung cancer tumors, in work from 2025. This cancer is among the most aggressive lung cancers and is hard to treat with precision methods. Its uniform look under the microscope hides wide molecular variety, and tissue for testing is often scarce.
The team ran a panel of over three hundred genes on fifty-five tumor samples, both primary and spread. Nearly all tumors had lost both copies of two key guard genes. Changes in a growth pathway were common, as were changes in genes that control DNA packing. One gene's changes were enriched in brain spread.
Catalog record
| CREATOR | Dániel Schmalz, Zoltán Krabóth, Veronika Czoma, Péter Urbán, Attila Gyenesei, István Ruzsics, Veronika Sárosi, Árpád Boronkai, Emőke Papp, Béla Kajtár, Maria Gazouli |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |