Lack of Negative Feedback Loops of CTLA-4 and PD-L1 as Key Mechanisms for Post-Acute T Cell Activation Until 3 Months After Ischemic Stroke
Lars Peglau, Johanna Ruhnau, Mara Winkelmann, Thomas Krüger, Alexander Dressel, Juliane Schulze, Antje Vogelgesang · 2025
Read Lack of Negative Feedback Loops of CTLA-4 and PD-L1 as Key Mechanisms for Post-Acute T Cell Activation Until 3 Months After Ischemic Stroke by Lars Peglau, Johanna Ruhnau, Mara Winkelmann, Thomas Krüger, Alexander Dressel, Juliane Schulze, Antje Vogelgesang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12691942.txt.
Description
Post-stroke T lymphocytes exert differential effects both at the infarction site and systemically; these are pro-inflammatory cascades, subsequent T cell infiltration into the brain, and persisting interaction of infiltrating T lymphocytes (more specifically a subset of CD4- CD8-double-negative T cells (DNTs)). Moreover, brain-resident microglia cells exacerbate the parenchymal damage.
Catalog record
| CREATOR | Lars Peglau, Johanna Ruhnau, Mara Winkelmann, Thomas Krüger, Alexander Dressel, Juliane Schulze, Antje Vogelgesang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |