β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies
Radwan Darwish, Yasmine Alcibahy, Ghena Abu-Sharia, Alexandra E. Butler · 2025
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Description
Mitochondria are essential for β-cell function, coupling glucose metabolism to ATP production and insulin secretion. In diabetes, β-cell mitochondrial dysfunction arises from oxidative stress, impaired quality control and disrupted dynamics, leading to reduced oxidative phosphorylation, defective insulin release and progressive cell loss.
Catalog record
| CREATOR | Radwan Darwish, Yasmine Alcibahy, Ghena Abu-Sharia, Alexandra E. Butler |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |