A Macrophage-Derived Factor on Human iPSC-Derived Cardiomyocyte Function: The Role of Osteopontin
Lei Hao, Eun Jung Lee · 2025
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Description
After a heart attack, immune cells flood in to clear the dead tissue, and Lei Hao and Eun Jung Lee ask what their signals do to surviving heart cells. Their 2025 study grows human heart muscle cells from stem cells and cultures them beside three kinds of macrophage. One partner stood out: the healing, anti-inflammatory M2 kind.
Beside M2 cells, the heart cells beat more slowly and their electrical signals stretched out, while two channel genes switched on harder. The shared fluid in those wells carried extra osteopontin, a macrophage-made factor. Adding osteopontin alone copied the changes, and blocking it undid them, which pins the effect on that factor. The authors suggest osteopontin as a fresh target for heart disease treatment.
Catalog record
| CREATOR | Lei Hao, Eun Jung Lee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |