The association between Sjogren’s disease and sex hormones: A case-control and Mendelian randomization study
Jing Zhang, Qi Sun, Anning Wang, Mengge Pan, Wenwei Wu, Zhi Lin, Qun Chen, Shu Liu · 2025
Read The association between Sjogren’s disease and sex hormones: A case-control and Mendelian randomization study by Jing Zhang, Qi Sun, Anning Wang, Mengge Pan, Wenwei Wu, Zhi Lin, Qun Chen, Shu Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12690054.txt.
Description
Jing Zhang and co-authors ask whether low estrogen drives Sjögren's disease or follows from it, in this 2025 study. The autoimmune disease dries eyes and mouth and strikes mostly women. In a hospital case-control study of postmenopausal women, patients showed lower estrogen, and low readings doubled the odds of disease.
A genetic method that mimics a natural experiment pointed the other way on cause: it suggested the disease itself drags estrogen down. The authors conclude low estrogen is a consequence of Sjögren's, not its trigger, which reframes hormone-based treatment hopes.
Catalog record
| CREATOR | Jing Zhang, Qi Sun, Anning Wang, Mengge Pan, Wenwei Wu, Zhi Lin, Qun Chen, Shu Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |