Macrophage migration inhibitory factor–CD74 axis drives vascular smooth muscle cell–induced M1 macrophage polarization to exacerbate intracranial aneurysm inflammation
Yao Chen, Jian-huang Huang, Qi-xiu Wang, Jian-hua Song, Jian-ning Chen · 2025
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Description
BackgroundIntracranial aneurysms (IAs) develop and progress through pathological processes, including inflammation and abnormal changes in the vascular structure. The cytokine Macrophage Migration Inhibitory Factor (MIF) is implicated in the pathology of vascular diseases. However, the role of MIF in IAs remains to be elucidated.MethodsTranscriptomic data from IA and normal arteries were analyzed to quantify MIF expression and immune infiltration (CIBERSORT).
Catalog record
| CREATOR | Yao Chen, Jian-huang Huang, Qi-xiu Wang, Jian-hua Song, Jian-ning Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |