Reversible formation of von-Willebrand-factor–platelet aggregates in microvascular blood flow
Alper Topuz, Masoud Hoore, Gerhard Gompper, Dmitry A Fedosov, Josh Wand · 2025
Read Reversible formation of von-Willebrand-factor–platelet aggregates in microvascular blood flow by Alper Topuz, Masoud Hoore, Gerhard Gompper, Dmitry A Fedosov, Josh Wand (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12687593.txt.
Description
Alper Topuz and co-authors simulate clotting strings that assemble and dissolve in tiny vessels in a 2025 study. A blood protein, von Willebrand factor, catches platelets to start clots, but in microvessels the aggregates behave cyclically. Their flow simulations trace the whole loop.
Red cells push the protein and platelets toward the wall, where fast shear stretches the protein open and aggregates grow. Past a size, lift peels the clump into the slow core, where it falls apart, and the cycle restarts. Shear activation of the protein and its grip on platelets set the rhythm. Small changes could yield either no clots or permanent ones, a balance the authors say matters for bleeding and clotting disorders.
Catalog record
| CREATOR | Alper Topuz, Masoud Hoore, Gerhard Gompper, Dmitry A Fedosov, Josh Wand |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |