Distinct roles of histone H2B ubiquitination at promoters and coding regions of Pol II-transcribed stress genes
Rubén Barrios, Montserrat Vega, Rebeca Gracia-Domingo, Susanna Boronat, Sarela García-Santamarina, Jason C. Tanny, José Ayté, Elena Hidalgo · 2025
Read Distinct roles of histone H2B ubiquitination at promoters and coding regions of Pol II-transcribed stress genes by Rubén Barrios, Montserrat Vega, Rebeca Gracia-Domingo, Susanna Boronat, Sarela García-Santamarina, Jason C. Tanny, José Ayté, Elena Hidalgo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12687531.txt.
Description
Barrios and colleagues show in twenty twenty-five that removing eraser enzymes for one histone mark rewires stress genes in fission yeast. Histone marks tag the spools DNA wraps on, guiding which genes switch on. Two erasers strip one such mark, and cells missing either eraser resist oxidative stress because their stress genes run hotter, even at rest.
The two erasers work in different gene zones: one at start sites within an activating complex, the other along gene bodies. Both losses raise related marks and loosen chromatin before stress hits. One loss still needs a partner complex for resistance, while the other does not. The authors map how mark crosstalk times gene activation.
Catalog record
| CREATOR | Rubén Barrios, Montserrat Vega, Rebeca Gracia-Domingo, Susanna Boronat, Sarela García-Santamarina, Jason C. Tanny, José Ayté, Elena Hidalgo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |