Posttransplantation clonal dynamics of hematopoietic stem cells carrying prenatal and early‐life DNMT3A mutations
Lucca L M Derks, Konradin F Müskens, Markus J van Roosmalen, Aniek O de Graaf, Nina Epskamp, Laurianne Trabut, Rico Hagelaar, Joop H Jansen, Caroline A Lindemans, Maaike G J M van Bergen, Ruben van Boxtel, Mirjam E Belderbos · 2025
Read Posttransplantation clonal dynamics of hematopoietic stem cells carrying prenatal and early‐life DNMT3A mutations by Lucca L M Derks, Konradin F Müskens, Markus J van Roosmalen, Aniek O de Graaf, Nina Epskamp, Laurianne Trabut, Rico Hagelaar, Joop H Jansen, Caroline A Lindemans, Maaike G J M van Bergen, Ruben van Boxtel, Mirjam E Belderbos (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12686829.txt.
Description
Derks and co-authors published a 2025 study tracing the roots of a pre-cancerous blood condition in people who had stem cell transplants as children. The condition, clonal hematopoiesis, appears when one blood stem cell with a mutation grows to fill a large share of the blood. The team studied three people, 14 to 41 years after transplant, whose blood carried mutations in a gene called DNMT3A.
By reading the full mutation record in their cells, the team rebuilt the family tree of the blood cells. The mutant stem cells were already present in the donors before age seven, and even before birth in one case. Standard tests at transplant time had missed them entirely. The clones then grew fast after transplant. The authors conclude that transplant conditions, more than new mutations, drive the growth.
Catalog record
| CREATOR | Lucca L M Derks, Konradin F Müskens, Markus J van Roosmalen, Aniek O de Graaf, Nina Epskamp, Laurianne Trabut, Rico Hagelaar, Joop H Jansen, Caroline A Lindemans, Maaike G J M van Bergen, Ruben van Boxtel, Mirjam E Belderbos |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |