Clonal cell states link gastroesophageal junction tissues with metaplasia and cancer
Rodrigo A Gier, Sydney A Bracht, Jiazhen Rong, Raúl A Reyes Hueros, Madison L Wahlsten, Christopher Cote, Maureen DeMarshall, Tatiana A Karakasheva, Alexandra Strauss Starling, Amanda B Muir, Gary W Falk, Nancy R Zhang, Sydney M Shaffer · 2025
Read Clonal cell states link gastroesophageal junction tissues with metaplasia and cancer by Rodrigo A Gier, Sydney A Bracht, Jiazhen Rong, Raúl A Reyes Hueros, Madison L Wahlsten, Christopher Cote, Maureen DeMarshall, Tatiana A Karakasheva, Alexandra Strauss Starling, Amanda B Muir, Gary W Falk, Nancy R Zhang, Sydney M Shaffer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12686426.txt.
Description
Rodrigo Gier and twelve co-authors trace the cell roots of Barrett's esophagus, a change in the food pipe lining that can lead to cancer. The team took cells from patients' healthy and changed tissue and followed each cell's family line while reading its gene activity. Lines of descent crossed borders that no one expected: some spanned the food pipe, the stomach top, and the junction between them.
Changed tissue held many separate cell families, each with all cell types. Early cancer-like growths, by contrast, grew from a single stray family. The paper gives a cell-level map of how this change starts and turns toward cancer.
Catalog record
| CREATOR | Rodrigo A Gier, Sydney A Bracht, Jiazhen Rong, Raúl A Reyes Hueros, Madison L Wahlsten, Christopher Cote, Maureen DeMarshall, Tatiana A Karakasheva, Alexandra Strauss Starling, Amanda B Muir, Gary W Falk, Nancy R Zhang, Sydney M Shaffer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |