Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing
Kun Lin, Shuai Fan, Xiaoqiang Yang, Wenyuan Hou, Junjiao Zhang, Jiaru Liao, Longfei Han, Peng Peng, Fangjun Xiao, Weihua Fang, Xianshun He, Jiaqing Tian, Shun Lu, Fan Yang, Qiushi Wei, Mincong He · 2025
Read Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing by Kun Lin, Shuai Fan, Xiaoqiang Yang, Wenyuan Hou, Junjiao Zhang, Jiaru Liao, Longfei Han, Peng Peng, Fangjun Xiao, Weihua Fang, Xianshun He, Jiaqing Tian, Shun Lu, Fan Yang, Qiushi Wei, Mincong He (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12686410.txt.
Description
Kun Lin and co-authors map the cells of joint lining tissue in hemophilic arthritis. The illness comes from repeat bleeding into joints in people with hemophilia. It wears the joint down, yet its cell profile was largely unknown. The team read single-cell gene activity in lining tissue taken during knee replacement surgery. They compared the map with maps from two other joint diseases.
The hemophilic map stood apart from both other diseases. Mast cells, rare in the others, were active here and may start leaks from vessels. Iron left by blood drove a cell death form called ferroptosis in vessel and support cells. One vessel cell type may steer support cells toward easing that death. The map names fresh targets for gene-based care.
Catalog record
| CREATOR | Kun Lin, Shuai Fan, Xiaoqiang Yang, Wenyuan Hou, Junjiao Zhang, Jiaru Liao, Longfei Han, Peng Peng, Fangjun Xiao, Weihua Fang, Xianshun He, Jiaqing Tian, Shun Lu, Fan Yang, Qiushi Wei, Mincong He |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |