Prospective validation of the prognostic and predictive impact of uPA/PAI-1 in early breast cancer
Vanessa Wieder, Julia Engel, Kathleen Eichstädt, Sandy Kaufhold, Marcus Bauer, Volker Hanf, Christoph Uleer, Susanne Peschel, Jutta John, Marleen Pöhler, Tilmann Lantzsch, Edith Weigert, Karl-Friedrich Bürrig, Jörg Buchmann, Eva Johanna Kantelhardt, Christoph Thomssen, Martina Vetter · 2025
Read Prospective validation of the prognostic and predictive impact of uPA/PAI-1 in early breast cancer by Vanessa Wieder, Julia Engel, Kathleen Eichstädt, Sandy Kaufhold, Marcus Bauer, Volker Hanf, Christoph Uleer, Susanne Peschel, Jutta John, Marleen Pöhler, Tilmann Lantzsch, Edith Weigert, Karl-Friedrich Bürrig, Jörg Buchmann, Eva Johanna Kantelhardt, Christoph Thomssen, Martina Vetter (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12686101.txt.
Description
Two tumor proteins may spare some breast cancer patients chemotherapy, and a 2025 study by Vanessa Wieder and co-authors puts the marker pair to a prospective test. The proteins, uPA and its blocker PAI-1, have been recommended in guidelines for judging risk in early breast cancer.
From a cohort of 1,270 patients, tumor tissue from 813 was tested with a standard kit. A patient counted as low status only if both proteins were low; that held for about thirty-eight percent. The study then tracked how status lined up with tumor features, time without recurrence, survival, and benefit from chemotherapy after surgery. Confirming a biomarker in routine care, not just in hindsight, is the point of the design.
Catalog record
| CREATOR | Vanessa Wieder, Julia Engel, Kathleen Eichstädt, Sandy Kaufhold, Marcus Bauer, Volker Hanf, Christoph Uleer, Susanne Peschel, Jutta John, Marleen Pöhler, Tilmann Lantzsch, Edith Weigert, Karl-Friedrich Bürrig, Jörg Buchmann, Eva Johanna Kantelhardt, Christoph Thomssen, Martina Vetter |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |