Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study
Gaia Brezzo, Kristy A Zera, Dana E Straus, Jennifer E Goertz, Sanna H Loppi, Rachel R Crumpacker, Jennifer B Frye, Danielle A Becktel, Maria Isabel Cuartero, Alicia García Culebras, Claudia Dames, Daniel Berchtold, Jill H Fowler, Andreas Meisel, Josef Anrather, Maria Angeles Moro, Stuart M Allan, Kr · 2025
Read Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study by Gaia Brezzo, Kristy A Zera, Dana E Straus, Jennifer E Goertz, Sanna H Loppi, Rachel R Crumpacker, Jennifer B Frye, Danielle A Becktel, Maria Isabel Cuartero, Alicia García Culebras, Claudia Dames, Daniel Berchtold, Jill H Fowler, Andreas Meisel, Josef Anrather, Maria Angeles Moro, Stuart M Allan, Kr (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12685733.txt.
Description
Many stroke survivors lose thinking skills over time, and no treatment exists yet, so animal studies must measure cognition reliably before drugs can be tested. Gaia Brezzo and co-authors ran a multi-center study in mice to see which tests detect post stroke thinking problems. They caused strokes three different ways and tested the mice with two standard tasks, one based on exploring new objects and one on learning a maze, before surgery and again weeks later. Brain damage and a blood marker of nerve injury were also measured.
The object test found no deficit. The maze test did catch worse performance in one stroke model. The authors draw lessons for the field: test choice and stroke model decide whether a real deficit is visible, and multi-site designs add their own difficulties. They recommend maze style validation across sites and give practical guidance for planning stroke cognition studies.
Catalog record
| CREATOR | Gaia Brezzo, Kristy A Zera, Dana E Straus, Jennifer E Goertz, Sanna H Loppi, Rachel R Crumpacker, Jennifer B Frye, Danielle A Becktel, Maria Isabel Cuartero, Alicia García Culebras, Claudia Dames, Daniel Berchtold, Jill H Fowler, Andreas Meisel, Josef Anrather, Maria Angeles Moro, Stuart M Allan, Kr |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |