Effect of Isoniazid Resistance on Treatment Outcome Among People With Pulmonary Tuberculosis in Korea
Jong Min Lee, Hyung Woo Kim, Eung Gu Lee, Yeonhee Park, Sung Soo Jung, Jin Woo Kim, Jee Youn Oh, Heayon Lee, Seung Hoon Kim, Sun-Hyung Kim, Jiwon Lyu, Sun Jung Kwon, Yun-Jeong Jeong, Dojin Kim, Hyeon-Kyoung Koo, Ganghee Chae, Sun Young Kyung, Sung Soon Lee, Jae Seuk Park, Ju Sang Kim, Jinsoo Min · 2025
Read Effect of Isoniazid Resistance on Treatment Outcome Among People With Pulmonary Tuberculosis in Korea by Jong Min Lee, Hyung Woo Kim, Eung Gu Lee, Yeonhee Park, Sung Soo Jung, Jin Woo Kim, Jee Youn Oh, Heayon Lee, Seung Hoon Kim, Sun-Hyung Kim, Jiwon Lyu, Sun Jung Kwon, Yun-Jeong Jeong, Dojin Kim, Hyeon-Kyoung Koo, Ganghee Chae, Sun Young Kyung, Sung Soon Lee, Jae Seuk Park, Ju Sang Kim, Jinsoo Min (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12685575.txt.
Description
Lee and co-authors show that tuberculosis resistant to just one first-line drug still worsens patients' outcomes in Korea. Resistance to isoniazid is the commonest form and often shrugged off in practice. Their 2025 study draws on a national cohort registry plus a prospective hospital cohort, together covering more than eleven thousand lung TB patients.
Unfavorable outcomes, a bundle of death, failure, dropout, and unfinished care, ran clearly higher in the resistant group in both cohorts. Adjusted odds were about one and a half to two times those of drug-sensitive disease. Serious drug reactions also clustered in the resistant group, while early sputum clearing did not differ. The authors urge taking single-drug resistance seriously.
Catalog record
| CREATOR | Jong Min Lee, Hyung Woo Kim, Eung Gu Lee, Yeonhee Park, Sung Soo Jung, Jin Woo Kim, Jee Youn Oh, Heayon Lee, Seung Hoon Kim, Sun-Hyung Kim, Jiwon Lyu, Sun Jung Kwon, Yun-Jeong Jeong, Dojin Kim, Hyeon-Kyoung Koo, Ganghee Chae, Sun Young Kyung, Sung Soon Lee, Jae Seuk Park, Ju Sang Kim, Jinsoo Min |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |