Efficacy based on dose-response and safety of bone marrow-derived mesenchymal stem cells for the treatment of osteoarthritis: a systematic review and meta-analysis
Elnaz Lohrasbi, Soraya Babaie, Hadi Hamedfar, Samira Pourzeinali, Vahideh Toopchizadeh, Azizeh Farshbaf-Khalili · 2025
Read Efficacy based on dose-response and safety of bone marrow-derived mesenchymal stem cells for the treatment of osteoarthritis: a systematic review and meta-analysis by Elnaz Lohrasbi, Soraya Babaie, Hadi Hamedfar, Samira Pourzeinali, Vahideh Toopchizadeh, Azizeh Farshbaf-Khalili (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12683818.txt.
Description
Lohrasbi and colleagues pool trial results in twenty twenty-five on stem cells from bone marrow as a treatment for worn joints. Such cells are a hopeful way to repair joint tissue and ease pain, but dose and safety were unclear. The team searched major databases and found a small set of sound trials covering over one thousand patients.
Pain and daily function showed no clear gain in the first few months after injection. Gains appeared by six months and peaked at one year. Lower cell doses worked as well as higher ones for pain relief. No serious side effects were reported in most trials. The authors urge larger, standard trials with long follow-up to pin down the best dose.
Catalog record
| CREATOR | Elnaz Lohrasbi, Soraya Babaie, Hadi Hamedfar, Samira Pourzeinali, Vahideh Toopchizadeh, Azizeh Farshbaf-Khalili |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |