Hypoxic migrasomes drive colorectal cancer liver metastasis by mediating CD5L+ macrophage efferocytosis via NRP2/PROX1 axis
Yuqi Luo, Yiwen Huang, Yaoxing Huang, Longzhen Chen · 2025
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Description
Yuqi Luo and co-authors trace a vesicle route for colon cancer spread to the liver in a 2025 study. Migrasomes are a newly found class of packages shed by moving cells. Their role in colorectal cancer metastasis was almost unknown before this work.
Under low oxygen, cancer migrasomes grew more active in tissue and cell tests. A mouse liver spread model and single-cell sequencing mapped what the packages do. They steer a macrophage cleanup act through a named two-protein axis. That cleanup, called efferocytosis, reshapes the tumor's immune setting in the liver's favor. Blocking the vesicle route could slow a deadly pattern of spread.
Catalog record
| CREATOR | Yuqi Luo, Yiwen Huang, Yaoxing Huang, Longzhen Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |