Is seeing believing?—signal differentiation in a preclinical transbronchial imaging study implementing a composite optical fiber bronchoscope to detect a folate receptor-targeted near-infrared fluorophore
Yoshihisa Hiraishi, Tsukasa Ishiwata, Theodore Husby, Yuki Sata, Alexander Gregor, Takamasa Koga, Hiroyuki Ogawa, Shinsuke Kitazawa, Fumi Yokote, Masato Aragaki, Kate Kazlovich, Andrew Effat, Nicholas Bernards, Hidenori Kage, Brian C Wilson, Kazuhiro Yasufuku · 2025
Read Is seeing believing?—signal differentiation in a preclinical transbronchial imaging study implementing a composite optical fiber bronchoscope to detect a folate receptor-targeted near-infrared fluorophore by Yoshihisa Hiraishi, Tsukasa Ishiwata, Theodore Husby, Yuki Sata, Alexander Gregor, Takamasa Koga, Hiroyuki Ogawa, Shinsuke Kitazawa, Fumi Yokote, Masato Aragaki, Kate Kazlovich, Andrew Effat, Nicholas Bernards, Hidenori Kage, Brian C Wilson, Kazuhiro Yasufuku (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12683438.txt.
Description
Yoshihisa Hiraishi and co-authors probed a pitfall in fluorescence-guided lung imaging: a glow that may not come from the tracer drug, in a 2025 study. Fluorescence imaging can track targets live during scope or surgery work, and a folate-targeted dye is a leading agent for lung tumors. The team asked how to tell true tracer signal from look-alikes.
They used an ultra-thin composite fiberscope to excite and read the dye in a mouse tumor model. A spectrometer on the same axis measured the signal's makeup. Human tumor cells that carry the folate receptor grew in the mice and were dosed with the dye. The study works out how signal origin can be verified.
Catalog record
| CREATOR | Yoshihisa Hiraishi, Tsukasa Ishiwata, Theodore Husby, Yuki Sata, Alexander Gregor, Takamasa Koga, Hiroyuki Ogawa, Shinsuke Kitazawa, Fumi Yokote, Masato Aragaki, Kate Kazlovich, Andrew Effat, Nicholas Bernards, Hidenori Kage, Brian C Wilson, Kazuhiro Yasufuku |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |