Differential Effect of Acute and Chronic Exercise on Cardiac Angiogenesis Regulator: The Role of mRNA HIF-1α and Its Negative Regulators of In Vivo Study
Putri Karisa, Nova Sylviana, Hanna Goenawan, Hanny Primadini Fitrianti, Setiawan · 2025
Read Differential Effect of Acute and Chronic Exercise on Cardiac Angiogenesis Regulator: The Role of mRNA HIF-1α and Its Negative Regulators of In Vivo Study by Putri Karisa, Nova Sylviana, Hanna Goenawan, Hanny Primadini Fitrianti, Setiawan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12677996.txt.
Description
Putri Karisa and co-authors test how short and long exercise programs change heart genes tied to blood vessel growth, in a 2025 rat study. A factor called HIF-1 alpha drives new vessel growth when oxygen runs low. Long training has been linked to lower levels of this factor, possibly because its brakes rise. The team measure the factor and two of its brakes in rat hearts.
Twenty rats ran on treadmills at a moderate pace, in a short 15-day plan or a long eight-week plan, with matched rest groups. Gene activity for the factor rose after both plans, and one brake, PHD, rose with it. The second brake showed no clear change. The authors read the pattern as a shift: fresh training leans on low-oxygen signals, while steady training shifts toward oxygen-based control. The work adds detail to how the heart adapts to lasting exercise.
Catalog record
| CREATOR | Putri Karisa, Nova Sylviana, Hanna Goenawan, Hanny Primadini Fitrianti, Setiawan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |