Telomere Length and Clear Cell Renal Cell Carcinoma: Unraveling Causal Mechanisms Through Integrative Genetic and Single-Cell Transcriptomic Analysis
Kaixiang Zhang, Congjun Huang, Jing Zhou, Kai Fan, Ming Ruan, Youping Xiao · 2025
Read Telomere Length and Clear Cell Renal Cell Carcinoma: Unraveling Causal Mechanisms Through Integrative Genetic and Single-Cell Transcriptomic Analysis by Kaixiang Zhang, Congjun Huang, Jing Zhou, Kai Fan, Ming Ruan, Youping Xiao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12677994.txt.
Description
Kaixiang Zhang and co-authors test whether telomere length causes a kidney cancer in this 2025 study. Telomeres are the caps that protect chromosome ends, shortening as cells divide. Clear cell renal cell carcinoma is the commonest kidney cancer and still poorly explained.
Two huge genetic cohorts, one near half a million people, fed a Mendelian randomization analysis. That method uses inherited variants as natural experiments to probe cause. Adjustments covered kidney disease, blood pressure, and smoking. Single-cell data then showed which kidney cells express the linked genes. The design separates real causal threads from mere correlation. Results could point to screening markers for a hard-to-catch cancer.
Catalog record
| CREATOR | Kaixiang Zhang, Congjun Huang, Jing Zhou, Kai Fan, Ming Ruan, Youping Xiao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |