Thiazolidinones: novel insights from microwave synthesis, computational studies, and potentially bioactive hybrids
Luan A Martinho, Victor H J G Praciano, Guilherme D R Matos, Claudia C Gatto, Carlos Kleber Z Andrade · 2025
Read Thiazolidinones: novel insights from microwave synthesis, computational studies, and potentially bioactive hybrids by Luan A Martinho, Victor H J G Praciano, Guilherme D R Matos, Claudia C Gatto, Carlos Kleber Z Andrade (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12667731.txt.
Description
Luan Martinho and co-authors develop a fast, microwave-based way to make thiazolidinones, a ring-shaped family of compounds with possible biological activity. Their route joins aromatic building blocks with one of two sulfur-containing rings under a mild catalyst. Microwave heating speeds the reaction and cuts the catalyst needed.
The method proved broad, giving dozens of products in yields up to nearly complete. It also built eight new hybrid molecules that fuse the ring to another drug-like scaffold, again in good yields. A detailed spectroscopic study explained missing signals in two products, and light studies showed their glow works through charge transfer inside the molecule.
Catalog record
| CREATOR | Luan A Martinho, Victor H J G Praciano, Guilherme D R Matos, Claudia C Gatto, Carlos Kleber Z Andrade |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |