Exploring Gut Microbe-Host Genes in Postpartum Depression: Mendelian Randomization and Transcriptomic Analysis
Ting Cong, Jing Liu, Li Yuan, Zhenchen Chu · 2025
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Description
Ting Cong, Jing Liu, Li Yuan, and Zhenchen Chu probed links between gut microbes and postpartum depression in a 2025 study. Depression after childbirth is common, and gut bacteria influence mood through several pathways. The team used Mendelian randomization, a genetic method that tests cause-like links in observational data.
They combined genetic data on 196 gut microbe groups with data on the condition. One bacterial family appeared to lower risk, while two other groups appeared to raise it. Checks for common biases and a gene-expression data set helped narrow which host genes might connect microbes to mood. The work offers candidate pathways, not proof, for a condition that needs better early warning signs.
Catalog record
| CREATOR | Ting Cong, Jing Liu, Li Yuan, Zhenchen Chu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |