Negative Impact of p21‐Activated Kinase 4‐Mediated AMP‐Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans
Jiacheng Du, Hwang Chan Yu, Young Jae Moon, Sun‐Jung Yoon, Seung‐Yong Seo, Byung‐Hyun Park, Eun Ju Bae · 2025
Read Negative Impact of p21‐Activated Kinase 4‐Mediated AMP‐Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans by Jiacheng Du, Hwang Chan Yu, Young Jae Moon, Sun‐Jung Yoon, Seung‐Yong Seo, Byung‐Hyun Park, Eun Ju Bae (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12664904.txt.
Description
Jiacheng Du and co-authors present a 2025 study of a protein that may drive muscle loss with age and illness. The protein, PAK4, was already known to blunt a key energy sensor in muscle. That blunting had been tied to poor sugar control. The team asked whether removing PAK4 from muscle protects mice from wasting. A steroid drug and nerve cutting were used to trigger wasting in the mice.
Mice without PAK4 in muscle resisted both kinds of wasting. A drug-like tool that destroys PAK4 gave the same protection. Blocking the protein also fixed cell power plant problems in the muscle. In human samples, wasted muscle held more PAK4 than healthy muscle. Higher levels went with weaker grip and lower muscle scores. The authors propose PAK4 as a target for drugs against muscle loss.
Catalog record
| CREATOR | Jiacheng Du, Hwang Chan Yu, Young Jae Moon, Sun‐Jung Yoon, Seung‐Yong Seo, Byung‐Hyun Park, Eun Ju Bae |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |